Zoloft Elimination Timeframe Statistics

The half-life of Zoloft (sertraline) in adults is approximately 26 hours, meaning that it takes about 5.5 days for the drug to be fully eliminated from the body.

Statistic 1

"The half-life of Zoloft is approximately 24 to 26 hours."

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Statistic 2

"Zoloft's primary active metabolite, desmethylsertraline, has a half-life of 62 to 104 hours."

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Statistic 3

"Because of the relatively long elimination half-life of sertraline, successive steady-state concentrations are reached after about a week of once-daily dosing."

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Statistic 4

"For most people, Zoloft will completely clear out of the body in 5 to 6 days."

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Statistic 5

"The elimination of Zoloft is biphasic with a mean terminal half-life of 15 to 25 hours."

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Statistic 6

"This medication may lead to withdrawal reactions, especially if the intake has been frequent and for an extended period."

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Statistic 7

"The effects of Zoloft can last up to 6 days after the last dose taken."

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Statistic 8

"The first phase of Zoloft’s elimination involves a half-life of up to 25 hours, while the second phase may last 2-3 days."

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Statistic 9

"Zoloft is excreted in the urine, with approximately 40-45% excreted as unchanged drug."

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Statistic 10

"Around one-third of the drug gets metabolized via first-pass hepatic metabolism."

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Statistic 11

"After two weeks of stopping Zoloft, the elimination is complete in most individuals."

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Statistic 12

"Both Zoloft and its metabolite are highly bound to plasma proteins."

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Statistic 13

"Chronic dosing of Zoloft at 50-200mg/day does not result in accumulation of the drug or of desmethylsertraline in the plasma."

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Statistic 14

"Only about 1-2% of sertraline is recovered in the urine unchanged."

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Statistic 15

"Zoloft with food increases its bioavailability by about 25%."

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Statistic 16

"The clearance of sertraline is reduced by about 40% in elderly individuals compared to young adults."

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Statistic 17

"In people with severe hepatic impairment, the half-life of sertraline can be extended to 52 hours."

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