Key Takeaways
- The overall incidence of uterine rupture during vaginal birth after cesarean (VBAC) is 0.5-0.9%
- In women with a previous low transverse cesarean scar attempting VBAC, uterine rupture occurs in 0.7% of cases
- Uterine rupture rate in trial of labor after one cesarean (TOLAC) is 1.36 per 1,000 cases
- Prior cesarean section increases rupture risk by 23-fold compared to unscarred uterus
- Oxytocin use during labor raises rupture risk by 2.3 times in VBAC
- Previous classical uterine incision is associated with 25-fold higher rupture risk
- Prolonged second stage of labor (>3 hours) linked to 2.5-fold risk increase
- Fetal heart rate decelerations occur in 68% of uterine rupture cases
- Maternal tachycardia (>100 bpm) present in 66% of cases
- Emergency laparotomy is required in 100% of confirmed cases
- Hysterectomy performed in 38% of rupture cases with massive hemorrhage
- Immediate cesarean delivery recommended upon suspicion
- Maternal mortality from rupture is 0-13% in developed countries
- Perinatal mortality rate is 6-22% in rupture cases
- Neonatal hypoxia affects 50% of fetuses in rupture
Uterine rupture risk remains low but increases with prior cesarean scars.
Incidence and Prevalence
- The overall incidence of uterine rupture during vaginal birth after cesarean (VBAC) is 0.5-0.9%
- In women with a previous low transverse cesarean scar attempting VBAC, uterine rupture occurs in 0.7% of cases
- Uterine rupture rate in trial of labor after one cesarean (TOLAC) is 1.36 per 1,000 cases
- Incidence of uterine rupture in unscarred uteri is 1 in 8,434 spontaneous labors
- Among multiparous women with unscarred uterus, rupture incidence is 0.012%
- Uterine rupture in women with prior classical cesarean section is 4.3-11.5%
- Global incidence of uterine rupture is estimated at 0.1% of all deliveries
- In developing countries, uterine rupture incidence reaches 0.24%
- U.S. national rate of uterine rupture during TOLAC is 0.72%
- Incidence increases to 3.7% with prostaglandin induction during VBAC
- Incidence of uterine rupture at term is 0.08%
- In grand multiparity (>5 births), incidence is 0.3%
- Rupture during first stage of labor: 55%
- Rupture during second stage: 35%
- Postpartum rupture incidence: 10%
- Rupture in twin pregnancies: 1.2%
- Incidence in obstructed labor: 10.8%
- Rupture in scarred uterus overall 0.47%
- VBAC rupture with epidural: 1.1%
- Rural vs urban incidence 0.35% vs 0.15%
- Rupture with breech presentation 1.8%
- Historical incidence pre-cesarean era 0.05%
Incidence and Prevalence Interpretation
Outcomes and Prognosis
- Maternal mortality from rupture is 0-13% in developed countries
- Perinatal mortality rate is 6-22% in rupture cases
- Neonatal hypoxia affects 50% of fetuses in rupture
- Hysterectomy rate post-rupture is 27%
- Long-term maternal psychological impact in 15-20%
- Fetal neurologic injury in 15% of survivors
- Recurrence risk after repair is 6.8%
- 91% VBAC success rate despite rupture risk
- Maternal mortality 13% in low-resource settings
- Perinatal mortality 16.5%
- Cerebral palsy risk 5.6% post-rupture
- Future pregnancy success 70% after repair
- Hysterectomy in 11% of unscarred ruptures
- 85% vaginal delivery success in subsequent pregnancy
- Maternal survival 99% in high-resource
- Fetal survival 79%
- Apgar <7 at 5min 45%
- PTSD incidence 18%
- Chronic pain post-repair 12%
- Recurrence after hysterectomy 0%
Outcomes and Prognosis Interpretation
Risk Factors
- Prior cesarean section increases rupture risk by 23-fold compared to unscarred uterus
- Oxytocin use during labor raises rupture risk by 2.3 times in VBAC
- Previous classical uterine incision is associated with 25-fold higher rupture risk
- Labor induction with prostaglandins increases risk to 2.45% in VBAC
- Macrosomia (>4,000g) elevates rupture risk by 2.7 times
- Multiparity without prior cesarean has OR 1.2 for rupture
- Interdelivery interval <18 months increases risk by 1.9 times
- Single prior low transverse cesarean has rupture risk of 0.5-1%
- Fetal malpresentation doubles the rupture risk
- Maternal age >35 years associated with OR 1.5 for rupture
- Previous myomectomy increases risk OR 5.9
- Shoulder dystocia history OR 2.1
- Placenta previa with prior CS: OR 3.4
- Obesity (BMI>30) OR 1.8
- Cocaine use OR 6.0 for rupture
- Uterine overdistension OR 2.5
- Misoprostol induction OR 7.1 in VBAC
- TOLAC after two cesareans: 3.7%
- Prior uterine rupture recurrence 5.8%
- Labor augmentation OR 2.4
- Gestational age >41 weeks OR 1.6
- Asian ethnicity OR 1.4
- Diabetes mellitus OR 2.0
- Preeclampsia OR 1.7
- Prior postpartum hemorrhage OR 1.9
- Fetal weight >4.5kg OR 3.2
- Oligohydramnios OR 1.5
Risk Factors Interpretation
Symptoms and Diagnosis
- Prolonged second stage of labor (>3 hours) linked to 2.5-fold risk increase
- Fetal heart rate decelerations occur in 68% of uterine rupture cases
- Maternal tachycardia (>100 bpm) present in 66% of cases
- Loss of station (fetal head retraction) noted in 35% of ruptures
- Abdominal pain reported in 78% of symptomatic ruptures
- Vaginal bleeding occurs in 25-50% of cases
- Shock (hypotension) in 30% of complete ruptures
- Ultrasound sensitivity for diagnosing rupture is only 71%
- MRI has 100% sensitivity for prenatal rupture detection
- Fetal bradycardia in 70%
- Palpation of fetal parts extrauterine in 10%
- CTG abnormalities in 89%
- Hemoperitoneum >2L in 40%
- Suprapubic tenderness in 80%
- Dehiscence vs complete rupture: 4:1 ratio
- Ultrasound shows free fluid in 85%
- Clinical diagnosis accuracy 92%
- Recession of presenting part in 28%
- Abnormal CTG precedes 87% ruptures
- Chest pain in 12%
- Cullen's sign rare, <1%
- Laparoscopy diagnostic yield 95%
- Free fluid on FAST exam 92% sensitive
- Hgb drop >4g/dL in 60%
Symptoms and Diagnosis Interpretation
Treatment and Management
- Emergency laparotomy is required in 100% of confirmed cases
- Hysterectomy performed in 38% of rupture cases with massive hemorrhage
- Immediate cesarean delivery recommended upon suspicion
- Fluid resuscitation and blood transfusion needed in 75% of cases
- Repair of rupture feasible in 70% without hysterectomy
- Uterine artery ligation used in 20% to control bleeding
- Mean time to diagnosis is 16.8 hours in some series
- Multidisciplinary team involvement reduces morbidity by 40%
- B-Lynch suture used in 15% for hemostasis
- Balloon tamponade success 65%
- Mean blood loss 2,500 mL
- Transfusion of >4 units in 50%
- Conservative management in stable patients 55%
- ICU admission rate 25%
- Operative mortality <1% with prompt intervention
- Repair time average 45 minutes
- O-negative blood ready in OR 100%
- Embolization success 80% in select cases
- Ventilation support 10%
- Prophylactic antibiotics 95% usage
- Postoperative imaging 30%





