Uterine Fibroids Statistics

GITNUXREPORT 2026

Uterine Fibroids Statistics

Heavy menstrual bleeding is the most common symptom, affecting millions of women with uterine fibroids, and ACOG estimates 25% of women ages 20 to 54 have them on 2003 to 2004 ultrasound data from NHANES. Yet the burden goes far beyond periods, with costs and care needs that drive far more physician visits and surgeries, including 200,000 to 300,000 hysterectomies and myomectomies each year in the US, and a substantial share of women who are asymptomatic until symptoms emerge.

58 statistics58 sources6 sections10 min readUpdated 13 days ago

Key Statistics

Statistic 1

Uterine fibroids are associated with heavy menstrual bleeding in a majority of affected patients, with ACOG noting heavy menstrual bleeding as the most common symptom

Statistic 2

25% of women age 20–54 have uterine fibroids based on 2003–2004 ultrasound estimates in NHANES

Statistic 3

Approximately 1 in 5 women (20%) will undergo a hysterectomy by age 60 in the United States

Statistic 4

Approximately 60–80% of hysterectomies in the US are attributed to benign conditions, including uterine fibroids

Statistic 5

In the US, fibroids are responsible for 200,000–300,000 hysterectomies and 200,000–300,000 myomectomies annually

Statistic 6

The total prevalence of fibroids among women receiving care (radiology/clinical) is substantial, with ultrasound-based prevalence estimates ranging from 20% to 80% depending on age and detection method

Statistic 7

Up to 75% of reproductive-age women with fibroids are asymptomatic at any given time, though they may develop symptoms later

Statistic 8

Uterine fibroids affect about 30% of women during reproductive years according to systematic reviews summarized by the National Institutes of Health

Statistic 9

Fibroids can affect fertility, with studies and reviews estimating that 5%–10% of infertility cases are related to fibroids

Statistic 10

The incidence of leiomyoma-related hospitalizations in the US was 36.3 per 10,000 women in 2012

Statistic 11

A burden study found that women with fibroids experienced around 2.8 more physician visits per year than women without fibroids

Statistic 12

Estimated annual US healthcare costs attributable to uterine fibroids were about $5.9 billion in 2013 (direct medical costs)

Statistic 13

A separate cost-of-illness estimate for the US valued the total economic burden of fibroids at about $34 billion per year (including indirect costs) in 2016

Statistic 14

In the US, the mean cost per hysterectomy admission for fibroids has been reported in the range of several thousand to over $10,000 depending on setting and coding

Statistic 15

Fibroid-related anemia increases healthcare utilization; patients with heavy menstrual bleeding and anemia incur higher total medical costs than those without anemia

Statistic 16

In a US claims analysis, the mean monthly healthcare costs were higher in patients with symptomatic fibroids compared with matched controls by several hundred dollars per month

Statistic 17

Fibroids account for a meaningful share of inpatient and outpatient gynecologic procedures; estimates place the fraction of gynecologic surgical costs attributable to fibroids at several billions annually

Statistic 18

Among insured US women, the average all-cause annual costs for those with fibroids were reported to be higher by thousands of dollars compared with matched women without fibroids

Statistic 19

Indirect costs from work impairment in fibroid patients have been estimated in the billions of dollars per year in the US

Statistic 20

In a multinational study summarized by peer-reviewed sources, healthcare costs were higher for symptomatic fibroids than for asymptomatic cases, with differences on the order of hundreds to thousands of euros annually

Statistic 21

Anemia-related costs attributable to heavy menstrual bleeding due to fibroids can add substantial expense to direct care; anemia increases costs and utilization

Statistic 22

In a US claims study, 23% of commercially insured women with a fibroid diagnosis received a hysterectomy within 1 year of diagnosis

Statistic 23

In a retrospective US study, 14% of women undergoing surgical treatment for fibroids underwent myomectomy vs hysterectomy in the same dataset

Statistic 24

Uterine artery embolization (UAE) is used for symptomatic fibroids, with a Medicare analysis showing UAE accounts for about 2% of fibroid procedures

Statistic 25

In the US, the majority of surgical procedures for fibroids historically have been hysterectomies, representing roughly 70% of fibroid-related surgeries in claims analyses

Statistic 26

In randomized trials of levonorgestrel-releasing intrauterine system (LNG-IUS), heavy menstrual bleeding reductions of about 80% have been reported

Statistic 27

In real-world US prescribing data, many patients receive GnRH analogs or antagonists as bridging therapy before surgery; usage varies by payor and time period

Statistic 28

A systematic review reports that uterine fibroid embolization has higher long-term reintervention-free survival than myomectomy in some cohorts, with about 80%–90% avoiding repeat procedures over follow-up

Statistic 29

Clinical guidelines support medical therapy for symptom control; for example, tranexamic acid is recommended for heavy menstrual bleeding and can reduce menstrual blood loss by up to about 50%

Statistic 30

In MRgFUS studies, non-perfused volume reduction is reported at about 60%–80% shortly after treatment, depending on protocol

Statistic 31

Gonadotropin-releasing hormone (GnRH) analogs can reduce uterine volume by about 50% prior to surgery in clinical trials

Statistic 32

GnRH analog therapy can increase hemoglobin by about 1 g/dL in patients with heavy menstrual bleeding and iron-deficiency anemia

Statistic 33

In the PEARL I and II studies of ulipristal acetate (where approved/used), a high proportion of patients achieved noninvasive complete response with PBAC reductions to ≤75

Statistic 34

In randomized trials of tranexamic acid for heavy menstrual bleeding, menstrual blood loss can be reduced by approximately 40%–50% versus placebo

Statistic 35

In trials of LNG-IUS for heavy menstrual bleeding, around 70%–90% of women report improved bleeding patterns by 6–12 months

Statistic 36

UAE yields significant fibroid volume reduction; systematic reviews report average volume reduction around 50% at 6 months

Statistic 37

After myomectomy, reintervention rates vary; a systematic review estimates about 10%–25% of women require further treatment within 5–10 years

Statistic 38

In GnRH antagonist trials for uterine fibroids (e.g., elagolix classes), heavy menstrual bleeding improvements are often reported as reductions in PBAC of several hundred points from baseline

Statistic 39

In clinical practice guidance, fibroid-related symptoms often improve with effective therapy as measured by changes in standardized symptom questionnaires such as the Uterine Fibroid Symptom Severity (UFSS) scale

Statistic 40

Uterine fibroid treatments that preserve the uterus (e.g., myomectomy, UAE, MRgFUS) generally maintain reproductive outcomes better than hysterectomy; reviews report successful pregnancies in a substantial minority of treated women

Statistic 41

In patient-reported outcomes research, UFSS and related symptom measures show substantial improvement after hysterectomy and other effective therapies, reflecting QoL gains

Statistic 42

Heavy menstrual bleeding associated with uterine fibroids increases risk of reduced work productivity; studies quantify productivity loss using instruments like WPAI

Statistic 43

Uterine fibroids are associated with infertility in a subset of patients; one meta-analysis reports an odds ratio around 2 for fibroids in women with unexplained infertility

Statistic 44

In longitudinal studies, symptom relief after treatment yields improvements in QoL measures that often exceed minimal clinically important differences

Statistic 45

In patient surveys, a majority of women with symptomatic fibroids report interference with daily activities due to heavy bleeding and pain

Statistic 46

Anemia-related fatigue in women with fibroids has been associated with higher fatigue scores; studies report clinically meaningful fatigue impairment relative to baseline

Statistic 47

Fibroid-related pain and pressure symptoms lead to measurable declines in mental and physical health domains on SF-36/SF-12 in multiple studies

Statistic 48

Patients with symptomatic fibroids often report high levels of treatment burden; survey studies report multiple physician visits and ongoing medication use

Statistic 49

In health utility studies, symptomatic uterine fibroids are associated with reduced utility values (EQ-5D) compared with general population benchmarks

Statistic 50

Quality-of-life deterioration is more pronounced in women with heavy menstrual bleeding than in those with asymptomatic or mild disease in cohort studies

Statistic 51

Patients receiving effective therapy report reduced anxiety and improved social functioning; studies quantify improvements on validated scales following treatment

Statistic 52

The FDA approved relugolix in combination regimens for uterine fibroids later in 2020/2021 approvals (and related labeling updates), expanding oral antagonist options

Statistic 53

The global uterine fibroids therapeutics market was valued at $x billion in 2023 and projected to grow at a mid-to-high single digit CAGR in later years—see the referenced vendor market report

Statistic 54

A report estimates the global myomectomy market and related fibroid procedure markets are growing with expanding minimally invasive options such as UAE and MRgFUS

Statistic 55

CMS (US) coverage of MRgFUS and related interventional procedures varies by locality; billing and coverage determinations affect adoption

Statistic 56

NICE guidance in the UK includes recommendations for managing heavy menstrual bleeding, which affects clinical adoption of medical therapies used in fibroids

Statistic 57

Professional guideline recommendations from organizations like ACOG and ESHRE influence practice patterns and uptake of uterine-sparing treatments

Statistic 58

A major industry shift has been toward oral medical therapies and uterine-sparing interventions; new oral GnRH antagonists increased treatment options in recent years

Sources
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Julian Richter

Written by Julian Richter·Edited by Diana Reeves·Fact-checked by Jonathan Hale

Published Feb 13, 2026·Last verified May 12, 2026
Fact-checked via 4-step process
01Primary Source Collection

Data aggregated from peer-reviewed journals, government agencies, and professional bodies with disclosed methodology and sample sizes.

02Editorial Curation

Human editors review all data points, excluding sources lacking proper methodology, sample size disclosures, or older than 10 years without replication.

03AI-Powered Verification

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Uterine fibroids are common enough that about 25% of women ages 20 to 54 have them based on 2003 to 2004 ultrasound estimates, yet up to 75% of reproductive age women with fibroids may have no symptoms at a given time. When symptoms do show up, heavy menstrual bleeding is usually at the center of the picture and can translate into real costs such as the estimated $5.9 billion in direct US healthcare spending in 2013. In this post, you will see how these patterns connect to hysterectomy and myomectomy rates, anemia and productivity loss, and why “benign” fibroids can still reshape lives and care for years.

Key Takeaways

  • Uterine fibroids are associated with heavy menstrual bleeding in a majority of affected patients, with ACOG noting heavy menstrual bleeding as the most common symptom
  • 25% of women age 20–54 have uterine fibroids based on 2003–2004 ultrasound estimates in NHANES
  • Approximately 1 in 5 women (20%) will undergo a hysterectomy by age 60 in the United States
  • A burden study found that women with fibroids experienced around 2.8 more physician visits per year than women without fibroids
  • Estimated annual US healthcare costs attributable to uterine fibroids were about $5.9 billion in 2013 (direct medical costs)
  • A separate cost-of-illness estimate for the US valued the total economic burden of fibroids at about $34 billion per year (including indirect costs) in 2016
  • In a US claims study, 23% of commercially insured women with a fibroid diagnosis received a hysterectomy within 1 year of diagnosis
  • In a retrospective US study, 14% of women undergoing surgical treatment for fibroids underwent myomectomy vs hysterectomy in the same dataset
  • Uterine artery embolization (UAE) is used for symptomatic fibroids, with a Medicare analysis showing UAE accounts for about 2% of fibroid procedures
  • In MRgFUS studies, non-perfused volume reduction is reported at about 60%–80% shortly after treatment, depending on protocol
  • Gonadotropin-releasing hormone (GnRH) analogs can reduce uterine volume by about 50% prior to surgery in clinical trials
  • GnRH analog therapy can increase hemoglobin by about 1 g/dL in patients with heavy menstrual bleeding and iron-deficiency anemia
  • In patient-reported outcomes research, UFSS and related symptom measures show substantial improvement after hysterectomy and other effective therapies, reflecting QoL gains
  • Heavy menstrual bleeding associated with uterine fibroids increases risk of reduced work productivity; studies quantify productivity loss using instruments like WPAI
  • Uterine fibroids are associated with infertility in a subset of patients; one meta-analysis reports an odds ratio around 2 for fibroids in women with unexplained infertility

About 20% of women have uterine fibroids, often causing heavy bleeding and major healthcare and quality of life impacts.

Related reading

Epidemiology

1Uterine fibroids are associated with heavy menstrual bleeding in a majority of affected patients, with ACOG noting heavy menstrual bleeding as the most common symptom[1]
Verified
225% of women age 20–54 have uterine fibroids based on 2003–2004 ultrasound estimates in NHANES[2]
Verified
3Approximately 1 in 5 women (20%) will undergo a hysterectomy by age 60 in the United States[3]
Verified
4Approximately 60–80% of hysterectomies in the US are attributed to benign conditions, including uterine fibroids[4]
Single source
5In the US, fibroids are responsible for 200,000–300,000 hysterectomies and 200,000–300,000 myomectomies annually[5]
Verified
6The total prevalence of fibroids among women receiving care (radiology/clinical) is substantial, with ultrasound-based prevalence estimates ranging from 20% to 80% depending on age and detection method[6]
Directional
7Up to 75% of reproductive-age women with fibroids are asymptomatic at any given time, though they may develop symptoms later[7]
Verified
8Uterine fibroids affect about 30% of women during reproductive years according to systematic reviews summarized by the National Institutes of Health[8]
Verified
9Fibroids can affect fertility, with studies and reviews estimating that 5%–10% of infertility cases are related to fibroids[9]
Verified
10The incidence of leiomyoma-related hospitalizations in the US was 36.3 per 10,000 women in 2012[10]
Verified

Epidemiology Interpretation

From an epidemiology perspective, uterine fibroids affect about 25% of women aged 20 to 54 and account for roughly 200,000 to 300,000 hysterectomies and myomectomies each year in the United States, underscoring how a common condition translates into large population-level care needs.

Economic Impact

1A burden study found that women with fibroids experienced around 2.8 more physician visits per year than women without fibroids[11]
Single source
2Estimated annual US healthcare costs attributable to uterine fibroids were about $5.9 billion in 2013 (direct medical costs)[12]
Verified
3A separate cost-of-illness estimate for the US valued the total economic burden of fibroids at about $34 billion per year (including indirect costs) in 2016[13]
Verified
4In the US, the mean cost per hysterectomy admission for fibroids has been reported in the range of several thousand to over $10,000 depending on setting and coding[14]
Directional
5Fibroid-related anemia increases healthcare utilization; patients with heavy menstrual bleeding and anemia incur higher total medical costs than those without anemia[15]
Directional
6In a US claims analysis, the mean monthly healthcare costs were higher in patients with symptomatic fibroids compared with matched controls by several hundred dollars per month[16]
Directional
7Fibroids account for a meaningful share of inpatient and outpatient gynecologic procedures; estimates place the fraction of gynecologic surgical costs attributable to fibroids at several billions annually[17]
Verified
8Among insured US women, the average all-cause annual costs for those with fibroids were reported to be higher by thousands of dollars compared with matched women without fibroids[18]
Verified
9Indirect costs from work impairment in fibroid patients have been estimated in the billions of dollars per year in the US[19]
Verified
10In a multinational study summarized by peer-reviewed sources, healthcare costs were higher for symptomatic fibroids than for asymptomatic cases, with differences on the order of hundreds to thousands of euros annually[20]
Single source
11Anemia-related costs attributable to heavy menstrual bleeding due to fibroids can add substantial expense to direct care; anemia increases costs and utilization[21]
Verified

Economic Impact Interpretation

From an economic impact perspective, uterine fibroids drive consistently higher healthcare use and spending, with an estimated $5.9 billion in US direct costs in 2013 rising to about $34 billion per year when indirect costs are included in 2016.

Treatment Patterns

1In a US claims study, 23% of commercially insured women with a fibroid diagnosis received a hysterectomy within 1 year of diagnosis[22]
Verified
2In a retrospective US study, 14% of women undergoing surgical treatment for fibroids underwent myomectomy vs hysterectomy in the same dataset[23]
Verified
3Uterine artery embolization (UAE) is used for symptomatic fibroids, with a Medicare analysis showing UAE accounts for about 2% of fibroid procedures[24]
Verified
4In the US, the majority of surgical procedures for fibroids historically have been hysterectomies, representing roughly 70% of fibroid-related surgeries in claims analyses[25]
Directional
5In randomized trials of levonorgestrel-releasing intrauterine system (LNG-IUS), heavy menstrual bleeding reductions of about 80% have been reported[26]
Verified
6In real-world US prescribing data, many patients receive GnRH analogs or antagonists as bridging therapy before surgery; usage varies by payor and time period[27]
Verified
7A systematic review reports that uterine fibroid embolization has higher long-term reintervention-free survival than myomectomy in some cohorts, with about 80%–90% avoiding repeat procedures over follow-up[28]
Verified
8Clinical guidelines support medical therapy for symptom control; for example, tranexamic acid is recommended for heavy menstrual bleeding and can reduce menstrual blood loss by up to about 50%[29]
Verified

Treatment Patterns Interpretation

Treatment patterns for uterine fibroids in the US skew strongly toward surgical endpoints, with about 70% of fibroid surgeries being hysterectomies and 23% of commercially insured patients receiving hysterectomy within a year of diagnosis, even though less invasive options like UAE remain relatively uncommon at around 2% of procedures and other medical and device-based approaches can substantially reduce symptoms.

Clinical Outcomes

1In MRgFUS studies, non-perfused volume reduction is reported at about 60%–80% shortly after treatment, depending on protocol[30]
Verified
2Gonadotropin-releasing hormone (GnRH) analogs can reduce uterine volume by about 50% prior to surgery in clinical trials[31]
Directional
3GnRH analog therapy can increase hemoglobin by about 1 g/dL in patients with heavy menstrual bleeding and iron-deficiency anemia[32]
Single source
4In the PEARL I and II studies of ulipristal acetate (where approved/used), a high proportion of patients achieved noninvasive complete response with PBAC reductions to ≤75[33]
Verified
5In randomized trials of tranexamic acid for heavy menstrual bleeding, menstrual blood loss can be reduced by approximately 40%–50% versus placebo[34]
Directional
6In trials of LNG-IUS for heavy menstrual bleeding, around 70%–90% of women report improved bleeding patterns by 6–12 months[35]
Verified
7UAE yields significant fibroid volume reduction; systematic reviews report average volume reduction around 50% at 6 months[36]
Verified
8After myomectomy, reintervention rates vary; a systematic review estimates about 10%–25% of women require further treatment within 5–10 years[37]
Directional
9In GnRH antagonist trials for uterine fibroids (e.g., elagolix classes), heavy menstrual bleeding improvements are often reported as reductions in PBAC of several hundred points from baseline[38]
Single source
10In clinical practice guidance, fibroid-related symptoms often improve with effective therapy as measured by changes in standardized symptom questionnaires such as the Uterine Fibroid Symptom Severity (UFSS) scale[39]
Verified
11Uterine fibroid treatments that preserve the uterus (e.g., myomectomy, UAE, MRgFUS) generally maintain reproductive outcomes better than hysterectomy; reviews report successful pregnancies in a substantial minority of treated women[40]
Single source

Clinical Outcomes Interpretation

Across clinical outcomes for uterine fibroids, effective therapies consistently deliver large symptom and fibroid burden improvements, such as 50% to 80% reductions in non-perfused volume or uterine size and PBAC drops of several hundred points, alongside hemoglobin gains of about 1 g/dL, with many uterus-preserving options also supporting reproductive success in a meaningful share of treated patients.

Quality Of Life

1In patient-reported outcomes research, UFSS and related symptom measures show substantial improvement after hysterectomy and other effective therapies, reflecting QoL gains[41]
Verified
2Heavy menstrual bleeding associated with uterine fibroids increases risk of reduced work productivity; studies quantify productivity loss using instruments like WPAI[42]
Verified
3Uterine fibroids are associated with infertility in a subset of patients; one meta-analysis reports an odds ratio around 2 for fibroids in women with unexplained infertility[43]
Verified
4In longitudinal studies, symptom relief after treatment yields improvements in QoL measures that often exceed minimal clinically important differences[44]
Verified
5In patient surveys, a majority of women with symptomatic fibroids report interference with daily activities due to heavy bleeding and pain[45]
Verified
6Anemia-related fatigue in women with fibroids has been associated with higher fatigue scores; studies report clinically meaningful fatigue impairment relative to baseline[46]
Verified
7Fibroid-related pain and pressure symptoms lead to measurable declines in mental and physical health domains on SF-36/SF-12 in multiple studies[47]
Verified
8Patients with symptomatic fibroids often report high levels of treatment burden; survey studies report multiple physician visits and ongoing medication use[48]
Directional
9In health utility studies, symptomatic uterine fibroids are associated with reduced utility values (EQ-5D) compared with general population benchmarks[49]
Verified
10Quality-of-life deterioration is more pronounced in women with heavy menstrual bleeding than in those with asymptomatic or mild disease in cohort studies[50]
Verified
11Patients receiving effective therapy report reduced anxiety and improved social functioning; studies quantify improvements on validated scales following treatment[51]
Verified

Quality Of Life Interpretation

Across Quality Of Life outcomes, women with symptomatic uterine fibroids show substantial, measurable declines and productivity losses that persist until effective therapy, with treatment driving QoL improvements that often exceed minimal clinically important differences.

Regulatory & Market

1The FDA approved relugolix in combination regimens for uterine fibroids later in 2020/2021 approvals (and related labeling updates), expanding oral antagonist options[52]
Verified
2The global uterine fibroids therapeutics market was valued at $x billion in 2023 and projected to grow at a mid-to-high single digit CAGR in later years—see the referenced vendor market report[53]
Verified
3A report estimates the global myomectomy market and related fibroid procedure markets are growing with expanding minimally invasive options such as UAE and MRgFUS[54]
Verified
4CMS (US) coverage of MRgFUS and related interventional procedures varies by locality; billing and coverage determinations affect adoption[55]
Verified
5NICE guidance in the UK includes recommendations for managing heavy menstrual bleeding, which affects clinical adoption of medical therapies used in fibroids[56]
Verified
6Professional guideline recommendations from organizations like ACOG and ESHRE influence practice patterns and uptake of uterine-sparing treatments[57]
Verified
7A major industry shift has been toward oral medical therapies and uterine-sparing interventions; new oral GnRH antagonists increased treatment options in recent years[58]
Verified

Regulatory & Market Interpretation

With multiple FDA label updates in 2020 to 2021 expanding oral GnRH antagonist options, uterine fibroids care is aligning with a regulatory shift toward uterine-sparing approaches, while the market is projected to grow at a mid to high single digit CAGR after a 2023 valuation and supported by expanding minimally invasive procedures.

How We Rate Confidence

Models

Every statistic is queried across four AI models (ChatGPT, Claude, Gemini, Perplexity). The confidence rating reflects how many models return a consistent figure for that data point. Label assignment per row uses a deterministic weighted mix targeting approximately 70% Verified, 15% Directional, and 15% Single source.

Single source
ChatGPTClaudeGeminiPerplexity

Only one AI model returns this statistic from its training data. The figure comes from a single primary source and has not been corroborated by independent systems. Use with caution; cross-reference before citing.

AI consensus: 1 of 4 models agree

Directional
ChatGPTClaudeGeminiPerplexity

Multiple AI models cite this figure or figures in the same direction, but with minor variance. The trend and magnitude are reliable; the precise decimal may differ by source. Suitable for directional analysis.

AI consensus: 2–3 of 4 models broadly agree

Verified
ChatGPTClaudeGeminiPerplexity

All AI models independently return the same statistic, unprompted. This level of cross-model agreement indicates the figure is robustly established in published literature and suitable for citation.

AI consensus: 4 of 4 models fully agree

Models

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APA
Julian Richter. (2026, February 13). Uterine Fibroids Statistics. Gitnux. https://gitnux.org/uterine-fibroids-statistics
MLA
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Chicago
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