GITNUXREPORT 2026

Pregnancy At 45 Statistics

Pregnancy at 45 is possible but faces very low odds and high medical risks.

Rajesh Patel

Team Lead & Senior Researcher with over 15 years of experience in market research and data analytics.

First published: Feb 13, 2026

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Statistic 1

Proportion of births to 45+ mothers: 3-5% in US

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First birth at 45+: 1%

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IVF usage 50% of pregnancies at 45

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Donor egg usage 40% at 45+

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Average age first birth rising to 27, but 45+ rising

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20% increase in 45+ births 2000-2020

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White women 45+ births 4%, Black 2%

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Urban areas 6% vs rural 2%

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Higher education correlates with delayed childbearing

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Europe 45+ birth rate 2 per 1000

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Asia low rates <1%

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Celebrity births at 45+ publicized 10/year

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Elective oocyte cryopreservation rising 20%/year

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Cost of IVF at 45: $20k/cycle average

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Insurance coverage low for 45+

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Global trend delayed fertility 15% women 40+

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UK 45+ births 1 in 200

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Australia 3% births to 40+

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Socioeconomic high SES 10x more 45+ births

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Divorced/widowed less likely

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Lesbian couples higher at 45+

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Pandemic increased 45+ attempts 10%

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Policy changes in China increased late births

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Women aged 45 have a natural monthly fertility rate of less than 1%

Statistic 25

At age 45, the chance of conceiving naturally within one year is about 1-5%

Statistic 26

IVF live birth rate for women 44-45 using own eggs is 1-2%

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Egg quality declines by 90% by age 45 compared to age 20

Statistic 28

Spontaneous pregnancy rate at 45 is 0.1% per cycle

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Donor egg IVF success at 45+ is 50-60%

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AMH levels average <0.5 ng/mL at 45

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Antral follicle count <5 at age 45

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FSH levels >25 IU/L typical at 45

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Cumulative live birth rate after 3 IVF cycles at 45: <5%

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95% of women 45+ need ART for conception

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Natural fecundity at 45: 0.5% per month

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Odds of live birth per cycle at 45: 1 in 200

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80% of eggs at 45 have chromosomal abnormalities

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Time to conception >12 months for 99% at 45

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Pregnancy rate with Clomid at 45: <5%

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IUI success at 45: 2-4%

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Live birth rate with frozen eggs at 45: negligible

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1 in 10 women 45+ conceive naturally

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AFC drops to 2-3 at 45

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Estradiol >100 pg/mL on day 3 poor prognosis at 45

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90% infertility rate at 45

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Per oocyte retrieval live birth <1% at 45

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Natural cycle IVF at 45: 0.5% success

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70% of 45+ use donor eggs successfully

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Miscarriage before confirming viability high at 45

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Conception odds drop 50% per year after 40

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99% of pregnancies at 45 require medical help

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Live birth per embryo transfer at 45: 2%

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Ovarian reserve depleted in 95% at 45

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Chromosomal abnormality risk 50% at 45

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Down syndrome risk 1 in 30 at 45

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Trisomy 18: 1 in 100 at 45

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Miscarriage rate 50-70% at 45

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Stillbirth rate 1-2% higher than younger

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Preterm birth 25-30%

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Low birth weight <2500g: 15-20%

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NICU admission 40%

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Congenital heart defects 2x risk

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Neural tube defects slightly increased

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IUGR 20%

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Macrosomia risk with GDM 30%

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Neonatal hypoglycemia 25%

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Respiratory distress syndrome 15%

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Jaundice requiring phototherapy 20%

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Autism risk 1.5x

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Cerebral palsy 2x

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Multiple gestation risks amplified

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Aneuploidy detection rate 90% via NIPT at 45

Statistic 73

Amniocentesis complication 0.5%

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CVS miscarriage risk 0.5-1%

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SGA infants 25%

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Perinatal mortality 2x baseline

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Hypoxic ischemic encephalopathy increased

Statistic 78

Long-term neurodevelopmental issues 1.5x

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Gestational hypertension risk 3x higher at 45+

Statistic 80

Preeclampsia incidence 20-30% at 45

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Gestational diabetes 15-25% at maternal age 45

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Placenta previa risk 2-4% at 45

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Cesarean section rate 60-80% at 45

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Postpartum hemorrhage 5x risk at 45

Statistic 85

Maternal mortality 4x higher at 45+

Statistic 86

VTE risk doubles every decade after 40

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Chronic hypertension 30% at 45 pregnancy

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Cardiac complications 10x at 45+

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Stillbirth risk 2-3% at 45

Statistic 90

Preterm labor 20% at advanced age

Statistic 91

Uterine rupture risk higher with prior C-section at 45

Statistic 92

Anemia incidence 40% at 45

Statistic 93

Thyroid dysfunction 15% in pregnancies at 45

Statistic 94

Severe maternal morbidity 50% higher

Statistic 95

Endometritis post C-section 10%

Statistic 96

HELLP syndrome 5x risk

Statistic 97

Oligohydramnios 15% at 45

Statistic 98

PROM risk increased 2-fold

Statistic 99

Perineal tear degree 3-4: 20%

Statistic 100

Postpartum depression 25% at advanced age

Statistic 101

Breastfeeding difficulties 30%

Statistic 102

Hysterectomy risk post-delivery 3x

Statistic 103

Renal failure acute 2%

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Sepsis 4x risk

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ARDS 5x

Statistic 106

Live birth rate overall 20-30% with interventions at 45

Statistic 107

Ongoing pregnancy rate 10% per IVF cycle at 45

Statistic 108

Multiple pregnancy rate 20% with IVF at 45

Statistic 109

Term delivery rate 60% of conceptions at 45

Statistic 110

Healthy baby rate ~70% with screening

Statistic 111

Ectopic pregnancy 5% risk at 45

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Elective C-section 70% at 45

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VBAC success 50% at advanced age

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Take-home baby rate 15% IVF own eggs 45+

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Cumulative success after 6 cycles ~25%

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Spontaneous abortion after 12 weeks 10%

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Twins complication rate 50% higher

Statistic 118

Overall survival to discharge 98%

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Bed rest requirement 40%

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Hospitalization antepartum 30%

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Induction of labor 50%

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Post-term pregnancy rare due to monitoring

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IVF cancellation rate 50% at 45

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Frozen transfer success 40% donor eggs

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PGT-A euploid rate 10% at 45

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Overall pregnancy rate 50% donor eggs

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Neonatal survival 99%

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5-min Apgar <7: 5%

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While the dream of a baby at forty-five burns bright for many, the stark biological reality is a monthly natural conception chance of less than one percent, launching a journey that is statistically one of medicine's most profound challenges.

Key Takeaways

Women aged 45 have a natural monthly fertility rate of less than 1%
At age 45, the chance of conceiving naturally within one year is about 1-5%
IVF live birth rate for women 44-45 using own eggs is 1-2%
Gestational hypertension risk 3x higher at 45+
Preeclampsia incidence 20-30% at 45
Gestational diabetes 15-25% at maternal age 45
Chromosomal abnormality risk 50% at 45
Down syndrome risk 1 in 30 at 45
Trisomy 18: 1 in 100 at 45
Live birth rate overall 20-30% with interventions at 45
Ongoing pregnancy rate 10% per IVF cycle at 45
Multiple pregnancy rate 20% with IVF at 45
Proportion of births to 45+ mothers: 3-5% in US
First birth at 45+: 1%
IVF usage 50% of pregnancies at 45

Pregnancy at 45 is possible but faces very low odds and high medical risks.

Demographic and Epidemiological Data

Proportion of births to 45+ mothers: 3-5% in US
First birth at 45+: 1%
IVF usage 50% of pregnancies at 45
Donor egg usage 40% at 45+
Average age first birth rising to 27, but 45+ rising
20% increase in 45+ births 2000-2020
White women 45+ births 4%, Black 2%
Urban areas 6% vs rural 2%
Higher education correlates with delayed childbearing
Europe 45+ birth rate 2 per 1000
Asia low rates <1%
Celebrity births at 45+ publicized 10/year
Elective oocyte cryopreservation rising 20%/year
Cost of IVF at 45: $20k/cycle average
Insurance coverage low for 45+
Global trend delayed fertility 15% women 40+
UK 45+ births 1 in 200
Australia 3% births to 40+
Socioeconomic high SES 10x more 45+ births
Divorced/widowed less likely
Lesbian couples higher at 45+
Pandemic increased 45+ attempts 10%
Policy changes in China increased late births

Demographic and Epidemiological Data Interpretation

While the Hollywood glow of celebrity announcements makes late motherhood seem almost trendy, the real statistics paint a more sobering picture of a costly, urban, and educationally-privileged frontier, where modern science grapples with ancient biology on a very steep financial curve.

Fertility and Conception

Women aged 45 have a natural monthly fertility rate of less than 1%
At age 45, the chance of conceiving naturally within one year is about 1-5%
IVF live birth rate for women 44-45 using own eggs is 1-2%
Egg quality declines by 90% by age 45 compared to age 20
Spontaneous pregnancy rate at 45 is 0.1% per cycle
Donor egg IVF success at 45+ is 50-60%
AMH levels average <0.5 ng/mL at 45
Antral follicle count <5 at age 45
FSH levels >25 IU/L typical at 45
Cumulative live birth rate after 3 IVF cycles at 45: <5%
95% of women 45+ need ART for conception
Natural fecundity at 45: 0.5% per month
Odds of live birth per cycle at 45: 1 in 200
80% of eggs at 45 have chromosomal abnormalities
Time to conception >12 months for 99% at 45
Pregnancy rate with Clomid at 45: <5%
IUI success at 45: 2-4%
Live birth rate with frozen eggs at 45: negligible
1 in 10 women 45+ conceive naturally
AFC drops to 2-3 at 45
Estradiol >100 pg/mL on day 3 poor prognosis at 45
90% infertility rate at 45
Per oocyte retrieval live birth <1% at 45
Natural cycle IVF at 45: 0.5% success
70% of 45+ use donor eggs successfully
Miscarriage before confirming viability high at 45
Conception odds drop 50% per year after 40
99% of pregnancies at 45 require medical help
Live birth per embryo transfer at 45: 2%
Ovarian reserve depleted in 95% at 45

Fertility and Conception Interpretation

While Mother Nature turns decidedly thrifty with her own biological supplies at forty-five, modern medicine, armed with donor eggs, can still engineer a remarkable, albeit costly, miracle.

Fetal and Neonatal Risks

Chromosomal abnormality risk 50% at 45
Down syndrome risk 1 in 30 at 45
Trisomy 18: 1 in 100 at 45
Miscarriage rate 50-70% at 45
Stillbirth rate 1-2% higher than younger
Preterm birth 25-30%
Low birth weight <2500g: 15-20%
NICU admission 40%
Congenital heart defects 2x risk
Neural tube defects slightly increased
IUGR 20%
Macrosomia risk with GDM 30%
Neonatal hypoglycemia 25%
Respiratory distress syndrome 15%
Jaundice requiring phototherapy 20%
Autism risk 1.5x
Cerebral palsy 2x
Multiple gestation risks amplified
Aneuploidy detection rate 90% via NIPT at 45
Amniocentesis complication 0.5%
CVS miscarriage risk 0.5-1%
SGA infants 25%
Perinatal mortality 2x baseline
Hypoxic ischemic encephalopathy increased
Long-term neurodevelopmental issues 1.5x

Fetal and Neonatal Risks Interpretation

The sheer number of potential hurdles laid out here feels less like a medical chart and more like a gauntlet, where every triumph over one statistic is a hard-won victory against daunting odds.

Maternal Health Risks

Gestational hypertension risk 3x higher at 45+
Preeclampsia incidence 20-30% at 45
Gestational diabetes 15-25% at maternal age 45
Placenta previa risk 2-4% at 45
Cesarean section rate 60-80% at 45
Postpartum hemorrhage 5x risk at 45
Maternal mortality 4x higher at 45+
VTE risk doubles every decade after 40
Chronic hypertension 30% at 45 pregnancy
Cardiac complications 10x at 45+
Stillbirth risk 2-3% at 45
Preterm labor 20% at advanced age
Uterine rupture risk higher with prior C-section at 45
Anemia incidence 40% at 45
Thyroid dysfunction 15% in pregnancies at 45
Severe maternal morbidity 50% higher
Endometritis post C-section 10%
HELLP syndrome 5x risk
Oligohydramnios 15% at 45
PROM risk increased 2-fold
Perineal tear degree 3-4: 20%
Postpartum depression 25% at advanced age
Breastfeeding difficulties 30%
Hysterectomy risk post-delivery 3x
Renal failure acute 2%
Sepsis 4x risk
ARDS 5x

Maternal Health Risks Interpretation

While the spirit of motherhood knows no age, the body at 45 presents a formidable statistical gauntlet where every potential joy is meticulously balanced against a sobering ledger of medical probabilities.

Pregnancy Outcomes and Success Rates

Live birth rate overall 20-30% with interventions at 45
Ongoing pregnancy rate 10% per IVF cycle at 45
Multiple pregnancy rate 20% with IVF at 45
Term delivery rate 60% of conceptions at 45
Healthy baby rate ~70% with screening
Ectopic pregnancy 5% risk at 45
Elective C-section 70% at 45
VBAC success 50% at advanced age
Take-home baby rate 15% IVF own eggs 45+
Cumulative success after 6 cycles ~25%
Spontaneous abortion after 12 weeks 10%
Twins complication rate 50% higher
Overall survival to discharge 98%
Bed rest requirement 40%
Hospitalization antepartum 30%
Induction of labor 50%
Post-term pregnancy rare due to monitoring
IVF cancellation rate 50% at 45
Frozen transfer success 40% donor eggs
PGT-A euploid rate 10% at 45
Overall pregnancy rate 50% donor eggs
Neonatal survival 99%
5-min Apgar <7: 5%

Pregnancy Outcomes and Success Rates Interpretation

While the journey at 45 is a statistical obstacle course where every hard-won victory is a triumph, the finish line, when reached, overwhelmingly holds a healthy, thriving baby.

Sources & References

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