GITNUX MARKETDATA REPORT 2024

Suboxone Opiate Blocking Duration Statistics

The opiate blocking effect of Suboxone typically lasts for around 24 to 48 hours after the last dose.

Last Updated: June 22, 2024

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In this post, we delve into the duration and effectiveness of Suboxone as an opiate blocker, exploring key statistics such as its prolonged blocking effect lasting up to 3 days, recommended target doses for opiate blocking, patient retention rates, and the impact of naloxone in enhancing its effects. Join us as we break down the data behind Suboxone’s role in opioid dependence treatment.

Statistic 1

"Suboxone’s blocking effect can last up to 3 days after a single dose."

Statistic 2

"Following administration, the opioid-blocking effect lasts at least 24 hours."

Statistic 3

"The recommended target dose of Suboxone to achieve opiate blocking is 16/4mg buprenorphine/naloxone per day."

Statistic 4

"Roughly three-quarters of patients were retained in treatment at the doses of suboxone 8 mg or higher."

Statistic 5

"The half-life of buprenorphine is 24–60 hours whereas that of naloxone is 2–12 hours."

Statistic 6

"For detoxification, a typical Suboxone treatment period might be 4-12 weeks."

Statistic 7

"The bioavailability of sublingual Suboxone tablets (due to first-pass metabolism) is approximately 30-55%."

Statistic 8

"A ceiling effect in respiratory depression has been observed with buprenorphine use, reducing the risk of overdose and increasing opiate-blocking duration."

Statistic 9

"Studies found that the presence of naloxone in Suboxone does not improve opioid blockade effect."

Statistic 10

"Injecting Suboxone yields a relatively smaller peak effect on opioids compared to oral administration - making it safer for opioid blocking."

Statistic 11

"Suboxone's effects last between 24 to 72 hours because of the long-acting nature of buprenorphine."

Statistic 12

"When taken sublingually, naloxone has virtually no effect, allowing the buprenorphine to exert its full effects for a longer duration."

Statistic 13

"A review indicated Suboxone's optimal dose range for maintenance treatment of opioid dependence is between 8mg/2mg and 24mg/6mg."

Statistic 14

"The bioavailability of buprenorphine in suboxone increases up to 50% when taken under the tongue compared to a swallowed tablet."

Statistic 15

"Buprenorphine has a longer half-life than naloxone, explaining why the opioid effects of Suboxone last much longer than the naloxone’s effects."

Statistic 16

"Naloxone in Suboxone is primarily added to deter misuse."

Statistic 17

"The peak plasma concentration (Cmax) of naloxone is typically reached 60-90 minutes post-dose."

In conclusion, Suboxone’s effectiveness in blocking opiates is supported by various statistics that highlight its long-lasting effects, recommended dosages, and mechanisms of action. The combination of buprenorphine and naloxone in Suboxone contributes to its extended duration of action and opioid-blocking capabilities. The optimal dosage range for Suboxone maintenance therapy, along with the route of administration, plays a crucial role in its efficacy. The addition of naloxone primarily serves as a deterrent against misuse, while buprenorphine’s long half-life explains why Suboxone’s effects can last up to several days. Overall, these statistics emphasize the importance of Suboxone in the treatment of opioid dependence and the considerations that should be taken into account for its effective use.

Jannik Lindner

Jannik is the Co-Founder of Gitnux and has been working in the digital space since 2016. He is specialized in content and tech.

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