GITNUX MARKETDATA REPORT 2024

Losartan Onset Duration Statistics

The onset of action of Losartan typically occurs within one to two hours after administration, with a duration of effect lasting up to 24 hours.

In this post, we will explore various statistical insights related to the pharmacokinetics and pharmacodynamics of Losartan. From its onset of action to its bioavailability and adverse effects reported by patients, we will delve into the key numerical facts surrounding the use of this medication. Let’s dive into the numbers behind Losartan’s onset, duration, metabolism, and more.

Statistic 1

"The onset of losartan's effect usually takes place within one week."

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Statistic 2

"The maximum blood pressure lowering effect would be reached 3-6 weeks after beginning therapy."

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Statistic 3

"The bioavailability for Losartan is approximately 33%."

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Statistic 4

"Losartan is metabolized to a 10–40 times more active metabolite."

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Statistic 5

"After oral administration of losartan, peak concentrations of losartan and its active metabolite are reached at 1 hour and 3-4 hours, respectively."

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Statistic 6

"The elimination half-life of losartan is about 2 hours and for the metabolite, it is about 6-9 hours."

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Statistic 7

"Less than 0.1% of patients reported a hypersensitivity to Losartan."

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Statistic 8

"Approximately 4% of patients reported dizziness when using Losartan."

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Statistic 9

"Nearly 8% of patients reported upper respiratory infection when using Losartan."

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Statistic 10

"Losartan has a volume of distribution of about 34 Liters."

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In conclusion, Losartan typically exhibits an onset of action within one week, with maximum blood pressure lowering effect occurring 3-6 weeks after beginning therapy. The drug’s bioavailability is approximately 33%, and it is metabolized to a significantly more active compound. Peak concentrations of losartan and its metabolite are reached at around 1 hour and 3-4 hours, respectively, following oral administration. The drug has relatively short elimination half-lives of about 2 hours for losartan and 6-9 hours for the metabolite. Reports of hypersensitivity to Losartan are minimal, with less than 0.1% of patients affected. Common side effects include dizziness in 4% of patients and upper respiratory infections in nearly 8% of users. Losartan’s volume of distribution is around 34 liters.

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