GITNUXSOFTWARE ADVICE
Science ResearchTop 10 Best Labware Lims Software of 2026
Ranked comparison of labware lims software for labs, with criteria and tradeoffs covering Dotmatics, LabWare LIMS, and STARLIMS.
How we ranked these tools
Core product claims cross-referenced against official documentation, changelogs, and independent technical reviews.
Analyzed video reviews and hundreds of written evaluations to capture real-world user experiences with each tool.
AI persona simulations modeled how different user types would experience each tool across common use cases and workflows.
Final rankings reviewed and approved by our editorial team with authority to override AI-generated scores based on domain expertise.
Score: Features 40% · Ease 30% · Value 30%
Gitnux may earn a commission through links on this page — this does not influence rankings. Editorial policy
Dotmatics is the best pick if you need instrument-connected LIMS with strict auditability across complex workflows, whereas Matrix Gemini fits when mid-size teams want barcode-centric sample movement, batch control, and practical instrument integration without going fully custom.
Editor’s top 3 picks
Three quick recommendations before you dive into the full comparison below — each one leads on a different dimension.
Dotmatics
Sample-linked run execution that connects instrument outputs back to the exact study context for traceable results.
Built for fits when labs need instrument-connected workflows with strict auditability..
LabWare LIMS
Editor pickConfigurable workflow-driven custody handling links sample, container, events, and reviewed results through governed status transitions.
Built for fits when regulated labs need customizable workflows across many instruments and strong custody traceability..
STARLIMS
Editor pickConfigurable plate and tube handling tied to barcoded sample workflows and storage location tracking.
Built for fits when regulated labs need configurable routing, instrument handoff, and specimen lifecycle control..
Related reading
Comparison Table
Labware LIMS software runs sample and assay workflows against a governed data model, then records audit-traceable results through configurable forms, RBAC, and instrument integrations. This ranked set is built for engineering-adjacent buyers who must compare extensibility, provisioning, throughput, and integration depth across platforms, without treating lab management as a black box.
Dotmatics
enterpriseScientific informatics platform offering LIMS, ELN, and data visualization.
Sample-linked run execution that connects instrument outputs back to the exact study context for traceable results.
Dotmatics supports sample tracking that links physical items to study context, plate layouts, and run executions. Workflow execution is driven by configurable states and assignments so that lab steps map to what staff actually do and what instruments generate. Data acquisition ingestion is designed around instrument-to-system handoff so acquired outputs land in the correct study context for review and reporting.
A tradeoff is that Dotmatics delivers more value when process definitions are invested up front through configuration of workflows, templates, and integrations. It fits teams that need instrument-linked workflows and consistent chain of custody across sample movement, labeling events, and result capture during active runs.
- +Instrument-linked workflow steps map captured outputs to the right samples
- +Configurable workflow states support repeatable run execution across teams
- +Role-based access controls limit access to studies, runs, and records
- +Audit trails provide traceable evidence for changes and activity history
- –Initial configuration for workflows and templates requires staff time
- –Complex integration paths can increase maintenance effort over time
- –Advanced automation needs design discipline in data mapping
- –Some lab-specific edge cases require service involvement
QC and regulatory operations
Run batch tracking with audit evidence
Faster investigations and consistent documentation
Biotech assay teams
Standardize multi-step method workflows
Lower variability between runs
Show 1 more scenario
Automation engineering groups
Connect instruments to structured records
Reduced manual data transfer
Uses integration interfaces to route acquired files into the correct sample and run.
Best for: Fits when labs need instrument-connected workflows with strict auditability.
More related reading
LabWare LIMS
enterpriseEnterprise LIMS and ELN platform for laboratory data management and sample tracking.
Configurable workflow-driven custody handling links sample, container, events, and reviewed results through governed status transitions.
LabWare LIMS fits labs that need a governed LIMS without forcing a fixed data capture model, because its configuration centers on workflows, lab objects, and status transitions rather than a single rigid template. Sample lifecycle handling includes custody tracking, labeling workflows, and result association to the originating specimens and containers. A strong integration focus shows up in instrument handoff patterns that can ingest data files, map fields, and drive downstream status changes into the LIMS work queue.
A key tradeoff is that deeper configuration and governance typically require dedicated admin time to model workflows, design templates, and maintain mappings for instruments and external payloads. This is a good fit when a lab must coordinate multiple instruments, support repeatable run batches, and keep audit records consistent across sample intake, analysis, and review steps.
- +Strong workflow configuration for sample intake to review steps
- +Inventory and multi-location control support freezer to rack moves
- +Instrument data ingestion driven by configurable mapping rules
- +Audit-focused change tracking for controlled result handling
- –Extensive setup effort is required to model lab workflows correctly
- –Usability depends on configuration quality for field layouts
- –Integration mapping work can grow with instrument diversity
- –Advanced governance controls often need admin ownership and review
Quality and compliance teams
Control result review and approvals
Consistent audit trail evidence
Analytical operations leads
Coordinate batches across instruments
Fewer manual rechecks
Show 2 more scenarios
Laboratory informatics engineers
Integrate instruments with file handoff
Automated status updates
Field mapping and data ingestion rules translate instrument outputs into LIMS objects and statuses.
Inventory coordinators
Track consumables and sample storage
Reduced stock discrepancies
Inventory and location hierarchy management supports transfers and controlled availability for scheduled work.
Best for: Fits when regulated labs need customizable workflows across many instruments and strong custody traceability.
STARLIMS
enterpriseAbbott Informatics LIMS for clinical, public health, and manufacturing laboratories.
Configurable plate and tube handling tied to barcoded sample workflows and storage location tracking.
STARLIMS supports end-to-end sample tracking with barcoding workflows, plate and tube models, and configurable statuses that map to lab operations. The configuration depth enables different accession rules, test routing, and result capture paths without rebuilding the application for each lab. Instrument connectivity and file-based handoff reduce manual transcription when instruments can export structured results or files for ingestion.
A tradeoff exists in the governance and configuration discipline needed to keep schemas, test methods, and routing rules consistent across sites. STARLIMS fits laboratories that run repeatable workflows at scale, where standardization of accessioning, testing, and disposition matters more than ad hoc processes.
- +Configurable sample lifecycle workflow with barcoding and controlled statuses
- +Instrument result ingestion via file handoff reduces transcription effort
- +Inventory and location tracking supports freezer and rack usage patterns
- +Audit trail support supports evidence needs during investigations
- –Requires careful configuration to prevent inconsistent test routing
- –Complex workflows can slow setup for new lab programs
- –Advanced integrations may require IT mediation for interface deployment
- –Some operational changes depend on administrative updates
Clinical lab operations
Route specimens through repeatable testing
Fewer manual handoffs
Lab IT integration teams
Ingest instrument output automatically
Reduced data re-entry
Show 2 more scenarios
Quality and compliance leads
Maintain traceability across changes
Better traceability
Use audit trail evidence to support investigations and review cycles.
Biorepository managers
Track specimens across storage locations
Lower misplacement risk
Maintain inventory positions across freezer and rack hierarchy with disposition controls.
Best for: Fits when regulated labs need configurable routing, instrument handoff, and specimen lifecycle control.
LabVantage LIMS
enterpriseConfigurable LIMS platform for industries spanning pharma, materials, and clinical labs.
Run batch management links plate maps, methods, and instrument handoff into a single execution context.
LabVantage LIMS combines sample tracking, plate and tube modeling, and workflow execution for end-to-end laboratory operations. The system supports instrument-to-LIMS file handoff and structured imports to move results into run context without manual rekeying.
Configuration for location hierarchy and barcoded handling supports controlled chain-of-custody patterns across multi-site lab setups. Strong audit evidence, method management, and operational automation focus on repeatable execution for regulated lab work.
- +Workflow execution engine ties sample, method, and run context to results handling
- +Location hierarchy modeling supports freezer to rack workflows for large inventories
- +Instrument file ingestion reduces manual result entry during batch processing
- +Audit log coverage supports regulated review trails across typical LIMS events
- –Requires upfront configuration of workflows and models to avoid operational drift
- –Extensibility depends on integrations that may require middleware ownership
- –Admin governance for complex roles can increase setup time for new labs
- –Custom interface work can be needed for niche instrument output formats
Best for: Fits when mid-size labs need workflow automation with instrument result ingestion and barcode-enabled custody.
Sapio Sciences
enterpriseNo-code LIMS and ELN platform for life sciences and clinical research.
Operational chain of custody that ties sample locations, run steps, and outcomes into one audit-ready workflow record.
Sapio Sciences manages laboratory sample and workflow records through a connected labware LIMS workflow. It focuses on traceable handling steps that link incoming materials, physical locations, and method execution into a single operational chain.
The system supports instrument and batch run tracking so laboratory staff can map results back to the specific samples and actions that produced them. It also provides administration controls for user permissions and controlled changes across lab operations.
- +Clear traceability from sample intake through run actions and outcomes
- +Supports instrument and batch run linkage to specific sample records
- +Location-aware handling for freezer, rack, and tube tracking
- +Permissioned workflows support controlled lab execution by role
- –Integration depth depends on instrument file handoff patterns
- –Import and migration workflows need careful data mapping work
- –Workflow configuration can become detailed for multi-step lab processes
- –Advanced governance evidence requires disciplined change procedures
Best for: Fits when medium labs need traceable sample workflows tied to instrument runs and controlled user permissions.
Matrix Gemini
vertical specialistConfigurable LIMS by Autoscribe Informatics for varied lab types.
Run batch governance that links barcode-identified labware to executed protocols and captured results under an audit trail.
Matrix Gemini from autoscribeinformatics.com targets labware and workflow execution for organizations that need traceable sample handling across runs. The system supports method and protocol management with run batch control and barcode-based tracking of tubes and plates.
Administration centers on configuration of lab entities, user roles, and audit logging to support governance for regulated lab operations. Integration relies on instrument-to-LIMS file handoff patterns and import-export cycles for exchanging run results.
- +Barcode-driven sample tracking across tubes and plates during run batches.
- +Run batch management ties protocols to executed work and results capture.
- +Audit logging supports traceability for chain of custody workflows.
- +Configurable inventory and location hierarchy for freezer, rack, and bucket setups.
- –Instrument integration breadth depends on instrument adapter and file handoff readiness.
- –Automation and workflow configuration can require careful upfront mapping of lab entities.
- –Export and data exchange workflows may be spreadsheet-centric for complex reporting.
- –UI ergonomics for high-volume ops can slow down bulk actions without templates.
Best for: Fits when mid-size labs need barcode-centric tracking, run batch control, and audit trails with practical integration to instruments.
LabLynx
SMBCloud-based LIMS and ELN for small to mid-sized laboratories.
Configurable inventory and location hierarchy drives barcoded movement validation across sample, plate, and tube workflows.
LabLynx focuses on labware-centric tracking, connecting barcoded items to a location hierarchy and enforcing movement through workflow steps. Sample tracking is coupled to run batch context so that handling events stay attached to the originating work order and material lineage.
The system includes audit logging for chain-of-custody needs and supports operational traceability across sample, plate, and tube entities. External interoperability is handled through data handoff mechanisms and API-based integration patterns for downstream ELN/LIMS interoperability and reporting systems.
Workflow execution supports run and batch management patterns and links instrument steps to sample outcomes. Configuration includes plate and tube models so that plate formats and container types map cleanly to how work is executed in the lab.
- +Inventory and location mapping tied to physical barcodes
- +Chain-of-custody event history connected to handling steps
- +Plate and tube models support common container formats
- +Instrument handoff can be driven via integration endpoints
- –Complex workflows require careful configuration of container models
- –RBAC granularity is not sufficient for highly segmented GMP roles
- –Audit log browsing can feel slow during high-throughput runs
- –Some integrations rely on file handoff patterns instead of streaming
Best for: Fits when mid-size labs need barcoded labware tracking with auditable sample movement across runs.
LabCollector
SMBOn-prem or cloud LIMS for sample tracking and lab inventory management.
A configurable storage and labware hierarchy that links sample state, inventory, and physical rack placement.
LabCollector is a laboratory LIMS and workflow system built around sample tracking, inventory control, and structured lab processes. It supports configuration of labware models and location hierarchies so plates, tubes, and storage locations map to physical reality.
Operational throughput is driven by workflow execution and status transitions that keep sample state consistent across runs. Integration breadth centers on data exchange for instrument handoff and import-export of run and sample information.
- +Configurable labware models and storage locations for freezer-to-rack tracking
- +Workflow status transitions keep sample lifecycle consistent across activities
- +Inventory and stock handling tied to locations and consumable usage
- +Structured data capture for runs and results with clear record lineage
- –Heavier configuration work than lighter sample trackers for new labs
- –Instrument integration depth depends on adopted handoff conventions
- –Complex workflow changes require admin attention to avoid state drift
- –Exports and imports may need careful mapping for custom result schemas
Best for: Fits when mid-size labs need controlled sample tracking plus workflow execution with labware and inventory mapping.
Bika LIMS
open sourceOpen source LIMS built on Plone for analytical and testing labs.
Bika LIMS provides lab-centric request and results configuration that adapts worksheets and reports to method-specific execution.
Bika LIMS tracks laboratory samples end to end using configurable workflows and a structured set of laboratory results and reporting steps. It focuses on laboratory execution artifacts such as test plans, instruments, and reporting templates to support repeatable run management and consistent outputs.
The solution is built for integration via import-export, extensibility through configuration, and external system handoff patterns common to lab environments. Administration centers on user roles and audit visibility for controlled change across investigations, results, and reporting.
- +Configurable lab workflows for sample-to-report execution steps
- +Strong support for test requests, results, and report templates
- +Location-aware inventory concepts for freezer-rack style tracking
- +Extensibility through configuration for lab-specific data fields
- –Integration surfaces depend on add-ons and custom work for deep automation
- –Complex configuration can slow initial rollout for multi-site labs
- –Limited out-of-the-box instrument integration middleware breadth
- –Audit visibility is present but governance controls need careful role design
Best for: Fits when labs need configurable sample workflows and repeatable reporting without heavy custom development.
Labguru
SMBAll-in-one lab management platform with ELN, inventory, and sample tracking.
Workflow automation rules that drive sample status, task assignment, and approval steps from structured lab events.
Labguru is a labware LIMS focused on sample tracking and end-to-end laboratory workflows with a configurable build. It supports plate and tube organization for tracking physical assets through experiments and into reporting outputs.
Labguru also includes instrument data handoff patterns for linking runs to samples, plus automation rules for assigning work and statuses. Audit-ready evidence is managed through controlled changes, user activity history, and electronic signature workflows where configured.
- +Configurable lab workflows map well to sample-to-result processes
- +Plate and tube tracking supports location hierarchy down to storage positions
- +Instrument run linkage reduces manual data transcription for many workflows
- +Built-in electronic signature workflows support review and approval steps
- –API and automation surface depth is less extensive than enterprise LIMS with middleware
- –Complex governance setups can take time for RBAC and audit coverage
- –Some advanced reporting and data modeling needs push teams into custom exports
- –Inventory and stock workflows may not match high-volume manufacturing use cases
Best for: Fits when mid-size labs need sample tracking with configurable workflows and clear approval trails.
Conclusion
After evaluating 10 science research, Dotmatics stands out as our overall top pick — it scored highest across our combined criteria of features, ease of use, and value, which is why it sits at #1 in the rankings above.
Use the comparison table and detailed reviews above to validate the fit against your own requirements before committing to a tool.
How to Choose the Right labware lims software
This buyer’s guide covers the labware-focused LIMS tools covered in the Top 10 Best Labware LIMS Software of 2026 article, including Dotmatics, LabWare LIMS, STARLIMS, LabVantage LIMS, Sapio Sciences, Matrix Gemini, LabLynx, LabCollector, Bika LIMS, and Labguru.
The guide turns the tool capabilities from the individual reviews into concrete selection criteria for instrument handoff, sample and container lifecycle control, inventory and location modeling, and auditability for regulated workflows.
Labware LIMS software for traceable sample, container, and instrument-to-result workflows
Labware LIMS software manages sample and container lifecycle records tied to workflows, instrument result ingestion, and run context so labs can track custody, outcomes, and approvals without relying on transcription.
Tools like LabWare LIMS and STARLIMS combine plate and tube handling with configurable routing and audit trails so each result links back to the exact specimen or container status at the time of execution.
For labs needing higher automation or instrument-connected traceability, Dotmatics coordinates labware, workflows, and instrument outputs by mapping results to the exact study context for end-to-end traceable reporting.
Evaluation criteria that map to real labware workflow and audit requirements
Labware LIMS selection succeeds when configuration and data flow match operational reality, not when features exist only on paper.
The criteria below focus on instrument-to-LIMS handoff, workflow and custody state control, plate and tube modeling tied to storage locations, and integration or automation surfaces that reduce manual mapping over time.
Instrument-to-sample result handoff with traceable run context
Dotmatics connects instrument-linked workflow steps back to the exact study context so results remain traceable through method execution. LabWare LIMS and STARLIMS also drive instrument data ingestion through configurable mapping or file handoff so results land in the correct governed record.
Governed custody and status transitions across sample and container states
LabWare LIMS ties sample, container, events, and reviewed results through configurable workflow-driven custody handling with governed status transitions. STARLIMS and LabVantage LIMS also enforce controlled statuses so specimen lifecycle control stays consistent during accession, processing, and reporting.
Run batch management that ties plate maps, methods, and instrument handoff together
LabVantage LIMS links run batch management into a single execution context by connecting plate maps, methods, and instrument file ingestion. Matrix Gemini focuses on run batch governance that links barcode-identified labware to executed protocols and captured results under an audit trail.
Barcode-driven labware tracking across plate, tube, inventory, and storage hierarchy
STARLIMS emphasizes configurable plate and tube handling tied to barcoded workflows and storage location tracking. LabLynx and LabCollector use configurable inventory and location hierarchy down to rack or storage positioning so barcoded movement validation stays consistent across sample, plate, and tube workflows.
Workflow execution and configuration that controls repeatability across teams
Dotmatics uses configurable workflow states to support repeatable run execution across teams while preserving role-based access controls and audit evidence. LabVantage LIMS also uses a workflow execution engine tied to sample, method, and run context so execution stays consistent under structured runs.
Administration controls for access control, audit trails, and controlled change evidence
Dotmatics provides role-based access controls for studies, runs, and records plus audit trails that record changes and activity history. LabWare LIMS and Sapio Sciences focus on controlled electronic review and permissioned workflows so audit-ready evidence stays attached to governed operations.
Select by workflow shape: intake to result, custody rules, and instrument integration reality
Labware LIMS choice should start with how samples and containers move through runs, how custody statuses change, and how instrument output becomes LIMS records.
After workflow shape is clear, the decision should narrow to the depth of governance controls and the practical integration surface used for instrument handoff and batch throughput.
Map custody and routing rules to each tool’s status-transition model
Labs with governed custody workflows should shortlist LabWare LIMS for configurable workflow-driven custody handling that links sample, container, events, and reviewed results through governed status transitions. Labs that need specimen lifecycle routing with barcoding should also evaluate STARLIMS because configurable plate and tube handling is tied to barcoded workflows and storage location tracking.
Match run batch design to how the lab executes plate maps and captures instrument output
If run batch management must unify plate maps, methods, and instrument handoff into one execution context, LabVantage LIMS fits because its run batch management links these elements into a single execution context. If barcode-identified labware governance under a run audit trail matters most, Matrix Gemini aligns because it links barcode-identified labware to executed protocols and captured results under an audit trail.
Choose the inventory and location hierarchy level based on physical storage operations
Labs that execute freezer-to-rack movement with strict physical positioning validation should look at LabLynx since its configurable inventory and location hierarchy drives barcoded movement validation across sample, plate, and tube workflows. Labs that need storage and labware hierarchy tracking that links sample state, inventory, and physical rack placement should also evaluate LabCollector.
Decide how instrument files become LIMS records, then confirm mapping flexibility and maintenance burden
Dotmatics is a strong fit when instrument outputs must be connected back to the exact study context through instrument-linked workflow steps for traceable results. LabWare LIMS, STARLIMS, and LabVantage LIMS also use instrument data ingestion through configurable mapping or file handoff, but those integrations can require careful instrument-to-LIMS mapping work as instrument diversity increases.
Pick the governance posture based on role segmentation and evidence expectations during audits
Teams needing role-based access to studies, runs, and records plus audit trails should prioritize Dotmatics because RBAC limits access and audit trails record changes and activity history. Labs that must manage permissioned workflows and controlled changes tied to approval steps should evaluate Sapio Sciences because it provides administration controls for user permissions and controlled changes across lab operations.
Who each labware LIMS tool fits best based on workflow and governance needs
Labware LIMS tools differ most in how they model plate and tube handling, how tightly they connect instrument data to run or study context, and how governance controls shape controlled change.
The segments below map tool fit to the audiences defined by each tool’s best-for statement.
Regulated labs that need strict auditability with instrument-connected study context
Dotmatics fits labs that need instrument-linked workflows with strict auditability because sample-linked run execution connects instrument outputs back to the exact study context for traceable results.
Regulated labs that need configurable workflows plus custody traceability across sample and container states
LabWare LIMS fits regulated labs that need customizable workflows across many instruments with strong custody traceability because configurable workflow-driven custody handling links sample, container, events, and reviewed results through governed status transitions.
Regulated labs that need configurable plate and tube routing with barcoding and specimen lifecycle control
STARLIMS fits regulated labs that need configurable routing, instrument handoff, and specimen lifecycle control because its configurable plate and tube handling ties barcoded sample workflows to storage location tracking.
Mid-size labs that need run batch execution that unifies plate maps, methods, and instrument file ingestion
LabVantage LIMS fits mid-size labs that need workflow automation with instrument result ingestion and barcode-enabled custody because its workflow execution engine ties sample, method, and run context to results handling and its run batch management links plate maps and instrument handoff.
Mid-size labs that need barcode-centric tracking and run batch audit governance
Matrix Gemini fits mid-size labs that need barcode-centric tracking, run batch control, and audit trails because run batch governance links barcode-identified labware to executed protocols and captured results under an audit trail.
Common failure modes when implementing labware LIMS tools
Implementation problems usually come from workflow modeling mismatches, integration mapping work that grows with instrument diversity, and governance that lacks the administrative ownership required for controlled change.
The mistakes below target issues described in the cons across the reviewed tools.
Underestimating workflow and template setup effort before onboarding new programs
LabWare LIMS and Dotmatics both require initial configuration of workflows and templates to reflect lab reality, so projects that start without dedicated configuration capacity tend to stall during rollout and new lab programs.
Allowing instrument-to-LIMS mapping to become an ongoing maintenance task
STARLIMS and LabWare LIMS can require careful configuration to prevent inconsistent test routing and mapping drift, so labs should standardize instrument handoff conventions before expanding instrument diversity.
Designing container and inventory models without staff ownership for governance consistency
Matrix Gemini and LabLynx both depend on careful upfront mapping of lab entities, so container-model complexity can create operational drift if governance roles and configuration ownership are not clearly assigned.
Assuming RBAC granularity and audit experience will work the same for all regulated role structures
LabLynx flags that RBAC granularity can be insufficient for highly segmented GMP roles, so labs with highly segmented role structures should validate role requirements against planned configuration before committing.
Relying on spreadsheet-centric exports and imports for advanced reporting needs
Matrix Gemini notes that export and data exchange workflows can be spreadsheet-centric for complex reporting, so labs that require highly structured analytics outputs should plan for custom exports or alternate reporting paths.
How We Selected and Ranked These Tools
We evaluated Dotmatics, LabWare LIMS, STARLIMS, LabVantage LIMS, Sapio Sciences, Matrix Gemini, LabLynx, LabCollector, Bika LIMS, and Labguru using a criteria-based scoring approach that assessed features, ease of use, and value from the documented capabilities described in the tool profiles. Features carried the most weight, while ease of use and value each accounted for the remainder of the overall score to reflect how quickly a lab can reach correct operational state.
Dotmatics set itself apart by combining instrument-linked workflow steps with sample-linked run execution that connects instrument outputs back to the exact study context for traceable results, and that capability lifted it primarily on the features factor because it directly affects end-to-end traceability.
Frequently Asked Questions About labware lims software
How do labware LIMS tools link sample records to instrument outputs during runs?
Which platforms handle barcoded plate and tube models with storage location tracking?
Which system design best supports chain of custody across configurable workflow status transitions?
How do integrations and automation typically work when instrument files need to enter the LIMS?
When do teams need electronic signature, audit trails, and admin governance controls?
What breaks if a lab requires instrument-connected workflows but the system relies only on manual data entry?
Which tools support data model extensibility through configuration hooks or import-export interfaces?
How should labs approach data migration when moving existing sample, inventory, and run history into a new LIMS?
What tradeoff appears when a team needs highly configurable plate and method routing versus fixed workflows?
Tools reviewed
Primary sources checked during evaluation.
Referenced in the comparison table and product reviews above.
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